Peptidylglycine alpha amidating
The first two domains are enzymes existing on the inside of the secretory granule, while the third domain is on the outside of the secretory granule.
PAL also requires a metal ion for activity; PAL contains zinc.Examples include the ACTH-secreting cells of the anterior pituitary, which stimulate cortisol secretion from the adrenal cortex but also secrete the opiate peptide beta-endorphin.The sister cells in the intermediate pituitary take the same peptide precursor, proopiomelanocortin, and make a skin darkening peptide called MSH, but little detectable ACTH. And how can the blend of peptides change during development?Hypothalamic peptides like oxytocin and vasopressin along with neuropeptides like substance P and gastrointestinal mediators like gastrin must be amidated in order to affect their target tissues.By purifying an enzyme capable of converting peptidylglycine precursors into amidated products, we were then able to clone a c DNA encoding this enzyme.
And the proopiomelanocortin neurons in the brain make other collections of peptides. Why do many sympathetic neurons make neuropeptide Y along with norepinephrine?